| Valence State and Oxygen Vacancy Engineering via Vanadium Doping in NiFe-LDHs for Highly Sensitive Non-enzymatic Glucose Detection |
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Suok Lee1, Yeonsu Park1, Huisu Jeong1, Eunwoo Park1, Yunhoe Koo2, Jong Bae Park3, Sang-Beom Han4, A-Rang Jang2, Juwon Lee5, Young-Woo Lee1,6 |
1Department of Energy Engineering, Soonchunhyang University, Asan 31538, Republic of Korea
2Division of Electrical, Electronic and Control Engineering, Kongju National University, Cheonan, Republic of Korea
3Honam Regional Center (Jeonju), Korea Basic Science Institute, Jeonju 54907, Republic of Korea
4Boyaz Energy Co. Ltd., Seoul 08590, Republic of Korea
5Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea
6Center of Advanced Energy Research, Soonchunhyang University, Asan 31538, Republic of Korea |
Correspondence:
A-Rang Jang,
Email: arjang@kongju.ac.kr
Juwon Lee,
Email: juwon.lee@skku.edu
Young-Woo Lee,
Email: ywlee@sch.ac.kr
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Received: 24 September 2025 • Accepted: 30 October 2025
*Suok Lee and Yeonsu Park contributed equally to this study as co-first authors. |
| Abstract |
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The growing global burden of diabetes necessitates the development of highly sensitive, stable, and cost-effective glucose-sensing technologies. Nonenzymatic electrochemical glucose sensors (NEGS) based on layered double hydroxides (LDHs) provide a durable and tunable alternative to enzyme-based sensors. Herein, we report a vanadium-doped nickel–iron LDH (NiFe₁₋ₓVₓ-LDH) system, hydrothermally grown on nickel foam, for enhanced glucose detection. Structural and spectroscopic analyses confirm that optimal vanadium incorporation (x = 0.4) modulates the lattice structure and defect chemistry, forming hierarchical nanoflower-like architectures with enhanced electroactive surface area. These features facilitate enhanced Ni²⁺/Ni³⁺ and V⁴⁺/V⁵⁺ redox transitions, improving charge transport and glucose oxidation kinetics. The optimized NiFe₀.₆V₀.₄-LDH electrode exhibits a high sensitivity of 1.891 mA mM⁻¹ cm⁻², a low detection limit of 2.228 μM, and excellent stability. This work highlights the synergistic role of valence-state engineering and defect modulation in designing advanced NEGS platforms, offering promising potential for future electrochemical sensing applications. |
| Keywords:
NiFe-LDHs, Valence state, Oxygen vacancy, Glucose, Selectivity |
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